The Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations

Exercise, in the form of endurance or resistance training, leads to specific molecular and cellular adaptions not only skeletal muscles, but also many other organs such as brain, liver, fat bone. In addition direct effects exercise on these organs, production release a plethora different signaling molecules from muscle are centerpiece systemic plasticity. Most studies have so far focused regulation function myokines acute bouts. contrast, secretome long-term training adaptation remains less well understood, contribution non-myokine factors, including metabolites, enzymes, microRNAs mitochondrial DNA transported extracellular vesicles by means, is underappreciated. this review, we therefore provide an overview current knowledge exercise-induced factors that mediate muscular adaptations training. Targeting leveraging their functions could broad implications for athletic performance, prevention therapy diseased elderly populations.